Risk of acute pancreatitis in COVID-19 patients

acute pancreatitis

Currently, the whole world is facing a health crisis owing to COVID-19, a viral infection caused by Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-Co-V2). COVID 19 was declared a pandemic disease by the World Health Organization in March 11, 2020, and the world continues to reel under its impact.

As it is known, this viral illness mainly involves the upper respiratory tract system. Apart from respiratory system, COVID-19 can impact the digestive system as well; nausea, vomiting and diarrhoea are its most common digestive symptoms. The COVID-19 virus may also impact the Pancreas. Incidence of Pancreas involvement in COVID-19 patients with Pneumonia is around 17%, but the degree of pancreatic involvement varies from patient to patient. Some patients can have an isolated rise in the pancreatic enzymes on their blood test without any clinical symptoms. There may be raised pancreatic enzymes on blood test and signs of Pancreatitis on imaging, but there will not be any clinical disease. Very rarely, there may be an overt episode of acute Pancreatitis; usually pancreatic involvement chances are less when COVID-19 disease is mild.

Also read: Portea Medical partners Delhi Govt for home isolation of COVID-19 patients

COVID-19 can cause pancreatic injury either by direct viral invasion, or indirectly via immune medicated injury. Pancreatic cells express particular type of receptors which is called as Angiotensin-Converting Enzyme 2 (ACE2) which helps the COVID-19 virus to move inside cells. The isolated pancreatic enzymes elevation on blood test should not be labelled as acute Pancreatitis among COVID-19 patients. Acute pancreatitis should be diagnosed in COVID-19 patients with raised pancreatic enzymes on blood test only when there is clinical disease and/ or imaging showing typical sign of acute Pancreatitis.


– Patients with acute Pancreatitis need supportive care like intravenous fluid, pain killers and nutrition

– Early aggressive intravenous fluid resuscitation and nutritional support is key to prevent serious complications of acute Pancreatitis, such as Pancreatic Necrosis

– If COVID-19 patients develop severe acute Pancreatitis, there is high risk of multi-organ failure and mortality

The COVID-19 virus can cause multi system involvement; although COVID-19 induced acute Pancreatitis is rare, it can cause severe damage to the patient as the target organ of both COVID-19 and Pancreatitis is the same. Both of them can cause severe inflammatory response. Upper abdominal pain among COVID 19 patients should be always evaluated from Pancreatitis point of view. Acute Pancreatitis among COVID-19 patients if not identified timely and managed properly, can be lethal.

(Disclaimer: The writer is Dr Swapnil Sharma, Consultant-Liver Transplant & HPB Surgery, Fortis Hospital, Mulund. Views expressed are a personal opinion.)

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