Metabolic health reflects how effectively the body processes and uses energy from food, determined by markers such as blood sugar, lipid profiles, blood pressure, and waist circumference. Maintaining a healthy metabolism helps reduce the risk of chronic conditions like type 2 diabetes, cardiovascular disease, and fatty liver. Adult obesity has tripled since 1975, with 1 in 8 adults now classified as obese [WHO]. More than 500 million adults live with diabetes, with steep increases projected in the coming decade [IDF]. Diets high in refined carbs, added sugars, unhealthy fats, and sodium are fueling poor metabolic outcomes worldwide.

According to Grand View Research, the global metabolic disorder therapeutics market was valued at USD 77.24 billion in 2024 and is projected to reach USD 120.71 billion by 2030, growing at a CAGR of 7.8%.

GLP1 and its effects

GLP-1 (Glucagon-Like Peptide-1) is a naturally occurring hormone in the human body that plays a central role in regulating blood sugar, appetite, and digestion. When we eat, GLP-1 is released from the gut, signalling the pancreas to produce insulin, slowing down stomach emptying, and sending satiety signals to the brain. This combination helps control blood sugar spikes and reduces overeating.

Rapid urbanisation, aggressive food marketing, and busy lifestyles are driving higher intake of calorie‑dense, ultra-processed, and fried/oily foods worldwide. These products are typically high in refined carbs, added sugars, unhealthy fats, and sodium while being low in fibre and micronutrients. Adult obesity has more than tripled since 1975; recent global estimates indicate roughly 1 in 8 adults are living with obesity [WHO].

Over 500 million adults are living with diabetes, with sharp growth projected over the next decade [International Diabetes Federation]. Diets high in sodium, sugar‑sweetened beverages, and processed foods are among the leading dietary factors which are increasing the risk factors, including elevated waist circumference, high triglycerides, high blood pressure, elevated fasting glucose, and low HDL cholesterol, indicating poor metabolic health. Maintaining metabolic health can help prevent chronic conditions such as type 2 diabetes, heart disease, fatty liver, and others.

Why is GLP1 trending?

Millions of posts and videos are circulating on platforms like TikTok, Instagram, and X. People are sharing personal transformation stories, “before & after” results, and lifestyle discussions linked to GLP-1 and metabolic health.  High-profile figures and influencers are openly talking about GLP-1, fuelling global curiosity and awareness. It has become part of mainstream pop culture, often discussed in entertainment and wellness circles.

The need for natural alternatives to GLP-1

While GLP-1 solutions are transformative, they face real-world challenges:

• Cost & Accessibility: Out of reach for many populations.
• Tolerance: Digestive discomfort and long-term dependency are common concerns.
• Sustainability: Rising demand calls for scalable natural solutions.

This is where nature-powered innovation is critical. Botanicals such as berberine, gymnema sylvestre, green tea, cinnamon, garcinia, and capsicum have long supported metabolic wellness. Modern research shows that these natural ingredients can positively modulate GLP-1 pathways, offering gentler, safer, and more accessible support.

Berberine and its challenges

Berberine is a naturally occurring alkaloid found in Berberine roots (Indian Barberry) and other plants. It is well-recognised for supporting metabolic health, cardiovascular function, and healthy lipid and glucose metabolism. 

Despite its proven benefits, conventional berberine extracts face significant limitations:

• Poor bioavailability: Less than 2% absorption into the bloodstream
• High dosage requirement: Typically, 500–1500 mg/day in divided doses
• Delayed onset of action
• Gastrointestinal side effects: Including diarrhoea, bloating, and nausea

Additionally, its low solubility slows therapeutic impact, making sustained results harder to achieve without long-term, high-dose use.

Also read: Transforming Clinical Trials in India: How Technology and AI Are Powering the Next Era of Patient-Centric Research

Other plant-based alternatives

Innovative, affordable, and long-lasting solutions are vital to address the global metabolic health crisis. The high cost, limited access, and side effects of GLP-1 agonists and traditional berberine highlight the need for natural, plant-based alternatives. Building on the proven benefits of botanical extracts, science is now enhancing their bioavailability and efficacy. For instance, Metaberine, a next-generation form of berberine, demonstrates how science can unlock higher potency and better absorption, raising the question of what other plant-based alternatives could similarly transform metabolic health.

Rather than relying on artificial substances, the future lies in harnessing the power of nature. By offering solutions that are effective, affordable, and globally scalable, we can help people restore their metabolic well-being in a more balanced and sustainable way.

Views expressed by: Dr. Arunkanth Krishnakumar, Co-founder & CEO, Zeus Hygia

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Disclaimer: The views and opinions expressed in this article are solely those of the author and do not necessarily reflect the official policy or views of any organisation. The content is intended for informational and educational purposes only and should not be construed as medical advice.

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