The ICMR in collaboration with a Hyderabad-based bio pharmaceutical company has developed “highly purified antisera” prepared by injecting inactivated SARS-CoV2 in horses, which can be a potential treatment for COVID-19.

“The ICMR and Biological E Limited, Hyderabad, have developed highly purified antisera (raised in animals) for prophylaxis and treatment of COVID-19,” the apex health research body was quoted saying by PTI report.

The ”antisera” is yet to undergo human clinical trials to establish its safety and efficacy and Drugs Controller General of India would be approached soon in this regard, Samiran Panda, the head of epidemiology and communicable diseases at the Indian Council of Medical Research (ICMR) said.

Also read: COVID-19: Reliance develops RT-PCR kit that can give test results in 2 hrs

Antisera are blood serum high in antibodies against specific antigens and are injected in humans to help kickstart the immune system to fight specific infections.

The pre-print version of the study regarding the development of the equine antisera has been posted on Research Square platform.

“The study provides evidence of the potential of generating highly purified F(ab”)2 from equines against SARS-CoV-2 that can demonstrate consistent and high neutralization activity. Further, in-vivo testing for efficacy of this indigenously developed, cost effective product will pave the way to clinical evaluation. Additionally, being a donor independent method, this may prove as an efficient alternative to convalescent plasma for treatment of COVID-19 patients,” the study paper was quoted saying by the report.

Earlier such measures were used for controlling several viral and bacterial infections.

“Although, plasma recovered from patients experiencing COVID-19 could serve similar purpose, the profile of antibodies, their efficacy and concentration keep varying from one patient to another and therefore make it an unreliable clinical tool for patient management,” the ICMR said in a tweet.

“Standardization achievable through equine sera based treatment modality thus stands out as yet another remarkable public health initiative supported by ICMR in the time of COVID-19,” it said.

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