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Managing cholesterol may reduce Alzheimer’s risk

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Managing cholesterol may help reduce Alzheimer’s risk, a team of researchers have found.

The study, conducted by a team of researchers, including one of Indian-origin, while examining DNA of over 15 lakh people found a genetic link between the progressive brain disorder and heart disease.

The study found risk factors for heart disease such as elevated triglyceride and cholesterol levels (HDL, LDL, and total cholesterol) were genetically related to Alzheimer’s risk.

Celeste M Karch, Assistant Professor at the Washington University’s School of Medicine, said: “The genes that influenced lipid metabolism were the ones that also were related to Alzheimer’s disease risk.”

The research, that took into account 90 points across the genome that were associated with risk for both diseases, noted that genes that contribute to other cardiovascular risk factors, like body mass index and Type-2 diabetes, did not seem to contribute to genetic risk for Alzheimer’s.

“If the right genes and proteins could be targeted, it may be possible to lower the risk for Alzheimer’s disease in some people by managing their cholesterol and triglycerides,” stated Rahul S Desikan, Assistant Professor at the UCSF while suggesting a possible solution in the light of the latest findings.

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