Indian Government is planning top launch Directly-Observed Treatment Short-Course (DOTS) Plus programme to fight with Tuberculosis (TB). World Health Organisation (WHO) and its partners have conceived the Dots Plus programme to control on TB in India. The programme is a strategy for the management of multi-drug resistant TB (MDR-TB). It uses second-line anti-TB drugs to cure MDR-TB. DOTS-Plus pilot projects are only recommended in settings where the DOTS strategy is fully in place to protect against the creation of further drug resistance. According to the 2006 annual Indian TB Report, Drug-resistant TB has been frequently encountered in India. The DOTS-Plus programme will make second-line drugs available in the country for people with MDR-TB.