Genetic Test to Predict Prostate Cancer Aggressiveness

Researchers are developing a genetic test to predict prostate cancer aggressiveness, which could save men with low-risk tumours from unnecessary surgery. Researchers at Queen Mary, University of London in the UK have found that men with high levels of cell-cycle progression genes are more likely to have aggressive prostate cancer tumours. In a study involving 703 men with prostate cancer, researchers found that men with the highest levels of cell-cycle progression genes were three times more likely to have a fatal form of prostate cancer. Among the patients who had surgery to remove their prostate, those who had the highest levels of cell-cycle progression genes were 70 percent more likely to have their cancer return. Lead researcher Jack Cuzick said that since cell-cycle progression genes are expressed at higher levels in actively growing cells, it is possible to measure the growth rate and inherent aggressiveness of the tumour through the new test.

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