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Epileptic Drugs Increases Risk of non-traumatic Fracture in Adults

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A new study has found that most anti-epileptic drugs are linked with an increased risk of non-traumatic fracture in older adults 50 years of age and older. The study has been published in the Archives of Neurology, one of the JAMA/Archives journals.The individual anti-epileptic drugs studied included carbamazepine, clonazepam, ethosuximide, gabapentin, phenobarbital, phenytoin and valproic acid. Additional anti-epileptic drugs with fewer numbers of users were included together under “other anti-epileptic drugs. The likelihood of fractures was highest for persons taking phenytoin followed by carbamazepine, other, phenobarbital, gabapentin and clonazepam.  Similar results were found when testing for the use of anti-epileptic drugs in monotherapy (individuals taking only one anti-epileptic drug) and in polytherapy (individuals taking more than one anti-epileptic drug). All anti-epileptic drugs used in immunotherapy were associated with a significantly increased risk of fracture except for valproic acid, phenobarbital and “other anti-epileptic drugs.” The greatest risk of fracture was found in individuals in the polytherapy subgroups.

 

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